Nanobodies Targeting Mouse/Human VCAM1 for the Nuclear Imaging of Atherosclerotic Lesions
نویسندگان
چکیده
منابع مشابه
Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of atherosclerotic lesions.
RATIONALE A noninvasive tool allowing the detection of vulnerable atherosclerotic plaques is highly needed. By combining nanomolar affinities and fast blood clearance, nanobodies represent potential radiotracers for cardiovascular molecular imaging. Vascular cell adhesion molecule-1 (VCAM1) constitutes a relevant target for molecular imaging of atherosclerotic lesions. OBJECTIVE We aimed to g...
متن کاملNanobodies Targeting Mouse/Human VCAM1 for the Nuclear Imaging of Atherosclerotic Lesions First author’s surname and short title: Broisat - Imaging Atherosclerosis with Anti-VCAM1 Nanobodies
1 Radiopharmaceutiques Biocliniques, INSERM, 1039, Université de Grenoble, La Tronche, France 2 In vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel (VUB), Brussels, Belgium 3 Department of Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium 4 Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgi...
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Rationale: A noninvasive tool allowing the detection of vulnerable atherosclerotic plaques is highly needed. By combining nanomolar affinities and fast blood clearance, nanobodies represent potential radiotracers for cardiovascular molecular imaging. Vascular cell adhesion molecule-1 (VCAM1) constitutes a relevant target for molecular imaging of atherosclerotic lesions. Objective: We aimed to g...
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متن کاملNuclear Imaging of Vulnerable Atherosclerotic Lesions
Coronary artery disease is the most important cardiovascular scourage that mankind has faced in the twentieth century. It will continue to be the leading cause of morbidity and death in the next century, both in men and women, and in developing and developed nations alike. The management of coronary artery disease has almost always been based on demonstration of the severity of luminal stenosis...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2012
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.112.265140